Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

Search Within Results

1,726 – 1,740 of 5,523 results

1,726

Apexbio Technology LLC AS 602801 848344-36-5 200mg

AS 602801 (CAS 848344-36-5) is a selective small-molecule inhibitor targeting c-Jun N-terminal kinase (JNK) a kinase implicated in immune and apoptotic signaling pathways Preclinical studies indicate that AS 602801 suppresses T-cell proliferation and promotes apoptosis altering gene expression in RRMS-derived CD4 and CD8 T-cells and innate receptor expression in RRMS-associated CD11b cells Animal models show beneficial effects in autoimmune disorders and neuronal apoptosis scenarios Thus AS 602801 is investigated primarily for therapeutic potential in multiple sclerosis and fibrotic conditions

Pricing & Availability

1,727

Apexbio Technology LLC SM-164 957135-43-2 200mg

SM-164 (CAS 957135-43-2) is a bivalent small molecule mimetic of the endogenous inhibitor Smac designed to antagonize cellular inhibitor of apoptosis proteins (cIAP-1 cIAP-2) and X-linked inhibitor of apoptosis protein (XIAP) By binding specifically to the BIR2 and BIR3 domains of cIAP-1 and XIAP as well as the BIR3 domain of cIAP-2 (Ki of 0 31 nM 0 56 nM and 1 1 nM respectively) SM-164 promotes degradation of cIAP-1 and inhibition of XIAP In tumor cells this leads to caspase activation and TNF -dependent apoptosis SM-164 is utilized in cancer research to investigate apoptosis regulation and anticancer therapy strategies

Pricing & Availability

1,728

Apexbio Technology LLC Rucaparib (free base) 283173-50-2 200mg

Rucaparib (free base) (CAS 283173-50-2) also known as AG014699 or PF-01367338 is a pharmacological inhibitor targeting poly(ADP-ribose) polymerase (PARP) a nuclear enzyme centrally involved in DNA damage signaling and base excision repair pathways By impeding PARP activity Rucaparib compromises DNA repair capacity leading to persistent DNA strand breaks as evidenced by increased gamma-H2AX and p53BP1 foci It has demonstrated radiosensitizing properties in prostate cancer cells notably those harboring PTEN deficiency or expressing ETS gene fusion proteins due partly to inhibition of non-homologous end-joining (NHEJ) DNA repair Rucaparib serves as a tool compound in oncology research to study chemosensitization and radiosensitization strategies

Pricing & Availability

1,729

Apexbio Technology LLC PF-543 1415562-82-1 200mg

PF-543 (CAS 1415562-82-1) is a cell-permeable inhibitor targeting sphingosine kinase 1 (SphK1) an enzyme that phosphorylates sphingosine to sphingosine-1-phosphate (S1P) It displays potent inhibitory activity against SphK1 with an IC50 of 3 6 nM through sphingosine-competitive (non-ATP competitive) binding Treatment of SphK1-overexpressing head and neck cancer (1483) cells led to a ten-fold decrease in S1P levels confirming effective target engagement PF-543 is widely utilized as a research tool in studies investigating SphK1-mediated signaling pathways in cancer biology and immune cell trafficking

Pricing & Availability

1,730

Apexbio Technology LLC MK-8245 1030612-90-8 200mg

MK-8245 (CAS 1030612-90-8) is a potent liver-selective small molecule inhibitor of stearoyl-CoA desaturase (SCD) SCD1 catalyzes fatty acid desaturation and represents a target for treating type II diabetes obesity dyslipidemia and other metabolic disorders MK-8245 demonstrates strong inhibitory activity against rat mouse and human SCD1 with an IC50 of approximately 1 nM and displays liver-specific tissue distribution mediated by organic anion transporting polypeptides (OATPs) Animal studies revealed MK-8245 reduces blood glucose levels and hepatic triglycerides dose-dependently supporting its application in metabolic disease research

Pricing & Availability

1,731

Apexbio Technology LLC Tideglusib 865854-05-3 200mg

Tideglusib is a potent selective inhibitor of glycogen synthase kinase-3 (GSK-3 ) functioning through irreversible and ATP-noncompetitive inhibition with reported IC50 of 60 nM Mechanistically Tideglusib binds in a manner independent of ATP leading to sustained enzyme inactivation Preclinical studies utilizing animal models demonstrate Tideglusib s ability to attenuate hyperphosphorylation of Tau protein reduce amyloid plaque accumulation prevent neuronal loss and enhance cognitive performance Currently undergoing clinical investigation Tideglusib has advanced through Phase II studies for Alzheimer s disease (AD) and progressive supranuclear palsy (PSP) exploring therapeutic applicability related to its GSK-3 inhibition activity

Pricing & Availability

1,732

Apexbio Technology LLC Cobicistat (GS-9350) 1004316-88-4 200mg

Cobicistat (GS-9350) is a selective inhibitor of cytochrome P450 3A enzyme (CYP3A) showing inhibitory activity with an IC50 ranging from 0 03 to 0 285 M in vitro It lacks intrinsic anti-HIV activity but serves primarily as a pharmacokinetic enhancer used in combination therapy to increase the systemic exposure of HIV-1 protease inhibitors such as atazanavir and darunavir Clinically cobicistat is administered orally to HIV-1-infected adults facilitating optimized dosing regimens Due to its selective CYP3A inhibitory mechanism cobicistat is employed in pharmacokinetic studies and drug-drug interaction investigations related to HIV treatments

Pricing & Availability

1,733

Apexbio Technology LLC GSK1838705A 1116235-97-2 200mg

GSK1838705A (CAS 1116235-97-2) is a small molecule inhibitor targeting the kinase activity of insulin-like growth factor-1 receptor (IGF-1R) insulin receptor and anaplastic lymphoma kinase (ALK) It exhibits potent inhibition with IC50 values of 2 0 nM for IGF-1R 1 6 nM for insulin receptor and 0 5 nM for ALK In preclinical research GSK1838705A suppresses proliferation of hematologic malignancy-derived tumor cells including multiple myeloma and Ewing sarcoma lines and inhibits tumor xenograft growth in vivo Additionally despite targeting the insulin receptor it minimally affects glucose homeostasis at effective doses Due to its multi-target kinase inhibitory profile GSK1838705A serves as a promising tool for cancer biology research

Pricing & Availability

1,734

Apexbio Technology LLC Ki16198 355025-13-7 200mg

Ki16198 (CAS 355025-13-7) is the methyl ester derivative of Ki16425 and functions as an antagonist of lysophosphatidic acid (LPA) receptors preferentially inhibiting LPA1 and LPA3 receptor subtypes Ki16198 reduces receptor-mediated inositol phosphate production with Ki values of 0 34 M (LPA1) and 0 93 M (LPA3) showing minimal inhibition of LPA2 and no significant activity against LPA4 6 In vitro Ki16198 attenuates LPA-induced proliferation migration invasion and proMMP-9 expression in cancer cells In vivo studies report suppression of pancreatic tumor growth metastasis and ascites formation highlighting its utility in investigating LPA-related cancer progression pathways

Pricing & Availability

1,735

Apexbio Technology LLC AMG-900 945595-80-2 200mg

AMG-900 (CAS 945595-80-2) is a small-molecule inhibitor targeting Aurora kinases a group of serine/threonine kinases crucial for mitosis regulation It exhibits potent ATP-competitive inhibitory activity against all three Aurora kinase isoforms resulting in suppression of Aurora-A and Aurora-B autophosphorylation events AMG-900 induces disruption of cellular mitotic processes leading to cell cycle arrest and subsequent apoptotic cell death Preclinically AMG-900 demonstrates activity across multiple tumor cell lines including multidrug-resistant and taxane-resistant variants and inhibits tumor growth in mouse xenograft models suggesting utility for cancer research

Pricing & Availability

1,736

Apexbio Technology LLC GSK1070916 942918-07-2 200mg

GSK1070916 (CAS 942918-07-2) is a selective ATP-competitive inhibitor targeting Aurora kinase B and C displaying Ki values of 0 38 nM and 1 5 nM respectively The compound demonstrates marked selectivity over Aurora kinase A with IC50 values of approximately 5 nM (Aurora B) versus 1259 nM (Aurora A) In vitro studies show that GSK1070916 inhibits proliferation of human lung cancer cells (A549) with an EC50 of roughly 7 nM Additionally the compound effectively reduces phosphorylation of histone H3 an Aurora B substrate and exhibits tumor growth inhibition in HL-60 xenograft mouse models GSK1070916 is utilized in tumor biology research investigating Aurora kinase signaling pathways

Pricing & Availability

1,737

Apexbio Technology LLC KU-60019 925701-49-1 200mg

KU-60019 is a selective inhibitor targeting ataxia telangiectasia mutated (ATM) kinase with an IC50 value of approximately 6 3 nM Through inhibition of ATM kinase activity KU-60019 influences cellular DNA damage responses and sensitivity to radiation therapy It has been demonstrated to enhance radiosensitivity in human fibroblast cells expressing functional ATM but not in ATM-deficient cells Additionally KU-60019 reduces radiation-induced phosphorylation of AKT at Ser473 in glioma cell lines independently affecting cell migration invasion and proliferation KU-60019 serves as an investigational tool for exploring ATM-dependent signaling pathways and examining therapeutic strategies against cancers involving ATM-regulated DNA repair and cell survival mechanisms

Pricing & Availability

1,738

Medchemexpress LLC HY-D0993 10mg Medchemexpress, Acridine Orange 10-Nonyl Bromide CAS:75168-11-5 Purity:>98%

Medchemexpress, HY-D0993 10mg Acridine Orange 10-Nonyl Bromide CAS:75168-11-5 Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λ ex : 489 nm, λ em : 525 nm). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

Pricing & Availability

1,739

Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 5mg, CAS: 130370-60-4.

Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development

Pricing & Availability

1,740

Medchemexpress LLC TRICLABENDAZOLE 200 mg

TRICLABENDAZOLE 200MG

Pricing & Availability

Quinolines and derivatives

Filtered Search Results

Narrow Results

Medchemexpress LLC HY-D0993 10mg Medchemexpress, Acridine Orange 10-Nonyl Bromide CAS:75168-11-5 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC TRICLABENDAZOLE 200 mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-D0993 10mg Medchemexpress, Acridine Orange 10-Nonyl Bromide CAS:75168-11-5 Purity:>98%

Medchemexpress LLC TRICLABENDAZOLE 200 mg